| abstract |
The present invention relates to a protein cysteine- (S) -thiosulfonic acid, which is a new oxidative modification of protein cysteine, and its use, and more particularly to a protein cysteine- (S) -thiosulfonic acid represented by the following formula (1) and to It relates to a biomarker containing as an active ingredient. The active cysteine- (S) -thiosulfonic acid of the protein according to the present invention is a product of an irreversible pathway that is different from the existing modifications in cysteine, which play an important role in the oxidation and reduction of the protein, and through additional reactions, the existing amino acid Loss of qualities can result in different characteristics. Therefore, cysteine- (S) -thiosulfonic acid according to the present invention can be used to measure the degree of oxidation of a disease-related protein, and accordingly various diseases related to reactive oxygen species (inflammatory disease, cancer, cardiovascular system, immune system, brain disease, etc.) It can be used as a biomarker of the antibody that can be analyzed can be used in clinical analysis. [Formula 1] Protein-Cys-SO 2 -SH |