| abstract |
In order to control the flow rate of the culture medium in the membrane separation tank without affecting the culture conditions in the culture tank, and to suppress the precipitation of microorganisms or cultured cells to increase the production efficiency of chemicals, Alternatively, the cultured cells are cultured, the culture solution is fed from the culture tank to the membrane separation tank, filtered through a separation membrane, the fermentation product is recovered from the permeate as a chemical product, and the unfiltered culture medium that has not been filtered is upstream from the membrane separation tank. In the method for producing a chemical product that is refluxed so as to join the culture medium on the side, a part of the culture solution fed from the culture tank is bypassed by the membrane separation tank in accordance with the pressure on the culture medium inflow side of the membrane separation tank. |