| abstract |
The present invention relates to 5-HT receptor modulators, in particular 5-HT 2B It is about antagonists. Novel piperidinylamino-thieno [2,3-d] pyrimidine compounds, and central nervous system disorders such as pulmonary arterial hypertension, congestive heart failure, hypertension, migraine, gastrointestinal disorders, restenosis, asthma, obstructive airway disease, prostate The use of the compounds for use in the treatment of diseases including hypertrophy and erectile dysfunction, anxiety, depression, schizophrenia, nerve damage and stroke is provided, as well as methods of preparation and novel intermediates and pharmaceutically acceptable salts thereof. . |