abstract |
The present invention relates to a crosslinked hyaluronic acid derivative insoluble in water and a method for producing the same, wherein the polymer or oligomer having two or more amine groups cross-links with hyaluronic acid or a cationic salt thereof through an amidation reaction.n n n The cross-linked hyaluronic acid derivative insoluble in water of the present invention may be used for various purposes such as anti-adhesion film, anti-wrinkle agent, molding aid and the like after surgery. |