http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-19990047897-A
Outgoing Links
| Predicate | Object |
|---|---|
| filingDate | 1997-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationDate | 1999-07-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | KR-19990047897-A |
| titleOfInvention | Cyclosporine-containing pharmaceutical composition |
| abstract | The present invention relates to a pharmaceutical composition containing cyclosporin as an active ingredient. The composition according to the present invention comprises a polyoxyethylene-polyoxypropylene block copolymers which can be used as a constituent of the cyclosporine, oil component, hydrophilic co-surfactant and the liquid phase at room temperature, It is characterized by suspending the outer phase by appropriately adjusting the composition ratio to form a microemulsion having a particle diameter of 100 nm or less. The composition of the present invention may be formulated in a pharmaceutical oral dosage form, that is, a soft capsule, or a hard capsule or an oral solution in which a junction is sealed by gelatin bending. Polyoxyethylene-polyoxypropylene block copolymers have a very wide range of applications, such as solubilizers, wetting agents, stabilizers, tablet coatings or additives, suppository bases, and especially have their own surfactant activation properties. Widely used as stabilizer. Polyoxyethylene-polyoxypropylene block copolymers which can be used as a hydrophilic co-surfactant and exhibit liquid at room temperature Cyclosporin-containing pharmaceutical composition used as a hydrophilic co-surfactant is formulated as a soft capsule in the prior art. Compared to the soft capsules prepared using ethanol, transcutol, propylene glycol, glycofurol, and dimethylisosorbide as co-surfactants, the drug's appearance due to the change in the appearance of the capsule caused by the gelatin membrane permeation of the solvent or the content of the solvent It is characterized in that it provides excellent advantages in suppressing precipitation formation, economic effect by reducing manufacturing cost, and toxicity problems of solvents that can come with long-term administration. |
| priorityDate | 1997-12-05-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 46.