http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102473092-B1
Outgoing Links
Predicate | Object |
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classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2517-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y201-01043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N2310-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K2227-105 |
classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-877 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0604 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01K67-0273 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Y201-01043 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-1137 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-8509 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N15-873 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N5-0606 |
classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-113 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-85 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01K67-027 |
filingDate | 2015-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
grantDate | 2022-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationDate | 2022-12-01-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
publicationNumber | KR-102473092-B1 |
titleOfInvention | Methods and compositions to increase somatic cell nuclear transfer (scnt) efficiency by removing histone h3-lysine trimethylation |
abstract | The present invention provides methods and compositions for improving the efficiency of somatic cell nuclear transfer (SCNT) and nuclear transfer ESCs (ntESCs) and subsequent production of transgenic cells and/or non-human animals. More specifically, the present invention relates to the discovery that trimethylation of histone H3-lysine 9 (H3K9me3) in the reprogramming resistance region (RRR) in the nuclear genetic material of donor somatic cells prevents efficient somatic cell nuclear reprogramming or SCNT. The present invention provides a method and composition for reducing H3K9me3 in a method for improving the efficiency of SCNT by inhibiting methylation of H3K9me3 by exogenous or overexpression of the demethylase Kdm4 family and/or by inhibiting the histone methyltransferases Suv39h1 and/or Suv39h2 provides |
priorityDate | 2014-09-15-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 2920.