http://rdf.ncbi.nlm.nih.gov/pubchem/patent/KR-102177196-B1

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filingDate 2020-02-14-04:00^^<http://www.w3.org/2001/XMLSchema#date>
grantDate 2020-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e36561323ab161133b738bf9d5d5eb70
publicationDate 2020-11-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-102177196-B1
titleOfInvention Nanoparticle multi-layered lamellar niosomes which is formed by nanoparticlation after being formed large niosomes in a supercritical state and cosmetic composition thereof
abstract The present invention relates to a cosmetic composition formed in a supercritical state and containing a multi-layered lamellar niosomal nanoparticles to enhance transdermal absorption and a method for producing the same, and more particularly, to a composite nonionic surfactant in a supercritical state ( After dissolving in the supercritical state) and adding the active ingredient, the large multi-layered niosomes formed in the sub-critical state coexisting with carbon dioxide are continuously passed through a high-pressure microfluidizer, and the nano-multilayered lamellar niosomes To prepare and provide a cosmetic composition with improved transdermal absorption, including this. In the present invention, sucrose distearate, polyglyceryl-10 dioleate, glyceryl monostearate, rapeseed sterol (Brassica campestris (Rapeseed) sterols) and dipotassium Using a complex nonionic surfactant containing phosphate (dipotassium phosphate) and using a multi-layered lamellar niosomes prepared through a supercritical method, various active ingredients in cosmetics can be stably delivered into the skin. In addition, the present invention has superior long-term stability compared to the use of liposomes prepared by a conventional manufacturing method using a conventional phospholipid base using multi-layered lamella niosomes, and has excellent transdermal absorption, skin moisturization, antioxidant efficacy and elasticity improvement. Can provide.
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