| abstract |
【Task】 Provided is a method for producing a liposome that has a high encapsulation rate, can be stably maintained, has no safety problem, and can be stored for a long period of time. [Solution] [1] Liposome membrane components including phospholipids and sterols, an aqueous solution of a water-soluble drug, and supercritical carbon dioxide in a pressure vessel at a temperature of 45-60 ° C. in the presence of a dissolution aid After mixing with Preparing an aqueous dispersion of liposomes encapsulating a water-soluble drug by depressurizing the inside of the pressure vessel and discharging carbon dioxide; Subsequently, the dispersion is subjected to pressure filtration at a temperature of 50 to 90 ° C. and 0.01 to 0.8 MPa using a filtration membrane having a pore size of 0.1 to 1 μm, and containing a liposome containing a drug inside Preparation method of the preparation. [Selection figure] None |