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publicationDate 2019-09-27-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber KR-102026100-B1
titleOfInvention Extremely small iron oxide nanoparticle based magnetic resonance imaging T1 agent
abstract Fine iron oxide nanoparticle cores; And micelles encapsulating the core particles, wherein the micelles comprise a nonionic surfactant containing a hydrophilic residue comprising at least two or more chains and a hydrophobic residue consisting of at least one C10 to C30 hydrocarbon chain. Magnetic resonance imaging T1 contrast agent is provided. Magnetic resonance imaging T1 contrast agent of the present invention is a new fine iron oxide nanoparticle-based T1 contrast agent that can replace the conventional gadolinium-based T1 contrast agent, harmless to the human body based on iron oxide nanoparticles, it is rapidly distributed in the blood and uniform in size It exhibits a uniform contrast effect. In addition, it is possible to observe the image up to 1 hour or more, up to 2 hours or more, and is discharged through the kidney and liver can solve the problem of the conventional gadlinium-based contrast agent.
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