| abstract |
The present invention provides a thermosensitive hydrogel composition comprising a nucleic acid and chitosan. The hydrogel is excellent in biocompatibility and biostability, and has a sol-gel phase transition property according to a temperature change. Therefore, the hydrogel exists as a sol state at room temperature. The hydrogel is injected into the human body or applied to the skin surface, When it becomes higher, it becomes gelled. Accordingly, the thermosensitive hydrogel of the present invention can be directly injected and applied to a specific site requiring treatment, and the drug can be sufficiently exhibited by increasing the retention time and adhesion time of the drug through gelation according to temperature, It is expected to be able to utilize. |