abstract |
The present invention relates to a human antibody that binds to the extracellular domain (ECD) of actin kinase-1 (ALK-1) and functions to inhibit the ALK-1 / TGF-beta-1 / Smad1 signaling pathway Antigen binding portion thereof. The present invention also relates to heavy and light chain immunoglobulins derived from human anti-ALK-1 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to a method of producing an anti-ALK-1 antibody of mankind, that is, a human, a composition comprising such an antibody, and a method of using the antibody and the composition. The invention also relates to a transgenic animal or plant comprising the nucleic acid molecule of the invention. |