| abstract |
The present invention relates to a nucleic acid delivery composition and a method for preparing the same, and more particularly, to a nucleic acid delivery composition and a method for producing the same, which are excellent in stability in the body environment, have excellent intracellular delivery efficiency of nucleic acid, and are capable of targeted delivery of nucleic acid. . Nucleic acid delivery composition and nucleic acid delivery composition provided according to the method of the present invention, which can completely conceal the nucleic acid from the external environment to prevent degradation of the nucleic acid by nucleic acid hydrolase when applied in vivo Therefore, the intracellular delivery efficiency is very excellent, and as the serum concentration increases, the intracellular nucleic acid delivery efficiency can be further increased, and thus, the serum stability, that is, the in vivo stability is excellent. In addition, the nucleic acid delivery composition includes an anionic polymer capable of targeted delivery to the outermost layer to allow targeted delivery of nucleic acids, and due to the cationic polymer having excellent endosomal escape ability included in the composition, Escape the endosome (endosome) made by the intracellular inhalation of the nucleic acid delivery composition can be delivered more effectively the nucleic acid into the cell. |