| abstract |
The present invention relates to a method for producing sustained-release microspheres containing a biodegradable polymer as a carrier by spray drying. More specifically, a process for preparing a solution, suspension or emulsion containing biodegradable polymers, drugs and solvents; Spray drying the solution, suspension or emulsion; And suspending the spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove residual solvent and increase the hydrophilicity of the surface of the microspheres. According to the production method of the present invention, it is possible to produce microspheres having a high drug encapsulation rate, little toxicity problem of residual solvent, and good injection ability. In addition, the microspheres prepared according to the present invention can be usefully used for the treatment of diseases by continually releasing the drug in effective concentrations for a period of time when administered in the body.n n n n Biodegradable polymer, sustained-release microsphere, spray drying method, polyvinyl alcohol, residual solvent removal, injection ability |