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filingDate 2018-10-18-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationDate 2020-12-24-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-WO2019130745-A1
titleOfInvention A method for creating a library used for predicting the action of a test substance on a living body and a method for evaluating the action of a test substance on a living body from changes in behavioral parameters of zebrafish, etc.
abstract It is a method to create a library in which a large number of numerical data obtained from changes in behavioral parameters of zebrafish and a large number of numerical data representing changes in gene expression levels are integrated and recorded, and its effects on living organisms are known. A step of preparing a substance having a known action, a step of measuring the behavioral parameters of a zebrafish to which the above-mentioned known action substance has not been administered in a water bath containing a zebrafish, and a step of measuring the above-mentioned action in a water bath containing the zebrafish A step of measuring the behavioral parameters of zebrafish after administration of the substance with known action in a water bath containing the substance and zebrafish, a step of detecting changes in the behavioral parameters of zebrafish due to administration of the substance with known action, and obtaining. The step of subdividing the data showing the changes in the behavioral parameters into a large number of numerical data, the step of normalizing the large number of numerical data obtained from the changes in the behavioral parameters, and the step of normalizing the large number of numerical data obtained from the changes in the behavioral parameters. The process of normalizing a large number of numerical data representing changes in expression level, all of which are normalized, and the large number of numerical data obtained from changes in behavioral parameters and the large number of numerical data representing changes in gene expression level. A method for creating a library used for predicting the action of a test substance on a living body, which is performed by the step of integrating and recording.
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