abstract |
The present invention is a novel nucleoside or nucleotide that can be used as a material for synthesizing nucleic acid pharmaceuticals. Formula (I): (wherein Y1 is CR6 or N, Y2 is CR7 or N, Y3 is CR8 or N, R6, R7 and R8 are each independently a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, etc., Bx is a nucleobase moiety, and Z1 and Z2 are each independently A hydrogen atom, a hydroxyl protecting group or a reactive phosphorus group, R1 to R5 are each independently a hydrogen atom, halogen, cyano, substituted or unsubstituted alkyl, and n is an integer of 0 to 3. Or a salt thereof. |