| abstract |
The present invention provides methods for antibody refolding, methods for producing refolded antibodies, refolded antibodies, and uses thereof. The present invention includes a step of denaturing an inactive antibody in which a peptide is linked directly or via a linker, wherein the peptide has an isoelectric point lower than that of the inactive antibody, and Provided is a method for refolding an antibody in a liquid phase, a method for producing a refolded antibody, and the like, comprising a step of dispersing the inactive antibody denatured in the above step and linked with the peptide in the liquid phase To do. |