| abstract |
PURPOSE: To control directiveness of a medicine to a targeted internal organ and to decrease disappearance rate of the medicine from blood by coating fat emulsifier particles with native polysaccharide derivative of specified structure to form an emulsifier. n CONSTITUTION: By mixing the fat emulsifier with the native polysaccharide derivative and stirring with a mixer, the fat emulsifier coated with the native polysaccharide derivative is obtd. The native polysaccharides is pullulan, amylose amylopectin, dextran or mannan, and one of the derivatives contains 0.5W5.0 saccharide units per 100 component saccharide units in the polysaccharid, prim. hydroxyl group on six-position carbon atom in these saccharide units being a group of formula I, where R 1 is H or cholesteryloxycarbonyl group. Therefore, in the amylose, the 0.5W5.0 saccharide units per 100 component units are saccharide unit of formula II. n COPYRIGHT: (C)1988,JPO&Japio |