| abstract |
NEW MATERIAL:A compound shown by formula I (R is H or lower alkyl; R 1 is 5W7C alkyl; broken line is alpha steric configuration of bond between stoms, wedge line is beta steric configuration of bond between stoms and wavy line is alpha of beta steric configuration of bond between atoms or mixture thereof) and a salt thereof. n EXAMPLE: (11S, 13E, 15S)-11, 15-dihydroxy-10, 10-dimethylo-9-oxoprost-13-en-1-oic acid methyl ester. n USE: Useful for treatment for human diseases as a drug effective for improving cerebral blood flow, peripheral circulation. peripheral blood circulation disorder, etc. n PREPARATION: A compound shown by formula III (R' is lower alkyl; R 2 is OH-protecting group) obtained by using 5,5-dimethyl-4-hydroxy-2-cyclopentenone shown by formula II as a raw material is deprotected and then hydrolyzed or hydrolyzed and deprotected to give a compound shown by formula I wherein R is H. n COPYRIGHT: (C)1988,JPO&Japio |