| abstract |
The present invention provides a method of treating ocular hypertension or glaucoma, comprising administering to the animal of ocular hypertension or glaucoma a therapeutically effective amount of a compound of formula I. In formula I, The dashed line indicates the presence or absence of a bond, the shaded wedge indicates the α (bottom) configuration, and the solid triangle indicates the β (top) configuration; B is a single, double or triple covalent bond; n is 0-6; X is CH 2 , S or O; Y is any pharmaceutically acceptable salt of CO 2 H, or CO 2 R, CONR 2 , CONHCH 2 CH 2 OH, CON (CH 2 CH 2 OH) 2 , CH 2 OR, P (O) (OR) 2 , CONRSO 2 R, SONR 2 , or Is; R is H, C 1-6 alkyl or C 2-6 alkenyl; R 2 and R 3 are C 1-6 straight chain alkyls which may be the same or different and may be joined together to form a ring incorporating the carbons to which they are attached together. |