| abstract |
PURPOSE: To efficiently obtain an optically active β-acyloxyacid ester and β- hydroxyacid ester, by biochemically carry out an asymmetric ester interchange reaction using (R, S)-β-hydroxyacid ester of racemic modification as a raw material. n CONSTITUTION: Ester interchange reaction is carried out in the presence of an enzyme, e.g. lipase, esterase, etc., having ability capable of reacting with a (R, S)-β-hydroxyacid ester expressed by formula I (X is 1W20C alkyl group- and preferentially subjecting ester of either one of R- and S-configurations to ester interchange reaction under condition substantially free from water. Said ester is preferably triglyceride, etc. The racemic ester compound can be separated into optically active β-hydroxyacid ester and β-acyloxyacid ester rich in either one of R- and S-configurations by said reaction. n COPYRIGHT: (C)1988,JPO&Japio |