| abstract |
NEW MATERIAL:The compound of formula I [X 1 and X 2 are halogen; R 1 and R 2 are H or alkyl or -NR 1 R 2 is group of formula, II, formula III (Y is O, S, etc.; R 6 is H, alkyl, hydroxyalkyl, etc.; R 4 and R 8 are H or alkyl; R 9 is H, alkyl, phenyl, etc.; R 10 is H, OH, NH 2 , etc.; R 11 is H or alkyl; m is 2 or 3; n is 3W5), etc.; R 3 and R 4 are H, alkyl, phenyl, etc., or -NR 3 R 4 is formula IV or formula V; R 5 is alkyl, alkenyl, phenyl, etc.], its ester and its salt. n EXAMPLE: 5-Amino-1-cyclopropyl-6,8-difluoro-7-(1-piperazinyl)-1,4--dihydro-4-oxo quinoline-3-carboxylic acid. n USE: An antibacterial agent. n PREPARATION: The compound of formula I can be produced by reacting the compound of formula VI (X is halogen) with the compound of formula R 1 R 2 NH in the presence of an acid acceptor. n COPYRIGHT: (C)1987,JPO&Japio |