http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-S62252798-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_746d8243701ae4271b74368451625bee |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-70 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07H21-02 |
| filingDate | 1986-11-25-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0d043247ca5ca8d7dba54fdbb080984e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ceffa93301f856020aefc0c700f92ee5 |
| publicationDate | 1987-11-04-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-S62252798-A |
| titleOfInvention | Nucleic acid derivative |
| abstract | PURPOSE: A nucleic acid derivative for antitumor agents, etc., composed of a polymer having stable high-order structure formed by substituting part of purine rings or pyrimidine rings of structural units with sulfur atoms and crosslinking to form disulfide bond of these sulfur atoms. n CONSTITUTION: A nucleic acid polymer containing cytidylic acid is dissolved in a mixed solvent of water with pyridine, introduced into a reactor together with liquefied hydrogen sulfide and reacted. Then the reactor is cooled down to remove the unreacted hydrogen sulfide. The resultant product is dissolved in a 50mM common salt-containing tris buffer solution and dialyzed to form a transparent liquid, followed by freeze-drying to substitute NH 2 group in the pyrimidine ring of the cytidylic acid in the molecule. Then this compound together with an equivalent amount of inosinic acid-containing nucleic acid polymer is dissolved in a buffer solution, kept warm at 68°C for 10min and 0.1N iodo-solution is added thereinto the effect reaction and obtain the aimed nucleic acid derivative having disulfide bonds. n COPYRIGHT: (C)1987,JPO&Japio |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-9961032-A1 http://rdf.ncbi.nlm.nih.gov/pubchem/patent/WO-03023031-A1 |
| priorityDate | 1986-01-06-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 41.