| abstract |
PURPOSE: To provide an agent for vaginal application, containing a carbonate and an acid. n CONSTITUTION: The objective agent can be prepared by mixing a carbonate (e.g. NaHCO 3 , Na 2 CO 3 , K 2 CO 3 , etc.) and an acid (e.g. citric acid, tartaric acid, ascorbic acid, dihydrogen sodium phosphate, etc.) at a ratio of 10:(3W30), especially 10:(3:W15), adding the mixture to an agent for vaginal application in an amount of 1W100wt%, especially 20W100wt%, and adding 0.1W40wt% pharmacologically active substance (e.g. nonsteroidal acidic anti-inflammatory agent such as aspirin, indomethacin, etc.; glucoamylase inhibitor; peptide-type antitumor substance such as bleomycin; enzymatic agent such as trypsin; gonadotropic hormone, etc.). n EFFECT: The congestion in the uterus can be dissolved when used in the menstrual period, and the functional dysmenorrhea can be mitigated. THe dysmenorrhea can be further improved by using the titled agent having pharmacological activity irrespective of the menstrual or intermenstrual period. n COPYRIGHT: (C)1986,JPO&Japio |