| abstract |
NEW MATERIAL:A compound shown by the formula I (R 1 is H or CH 3 ; R 2 is Cl, CH 3 , or phenyl which may be replaced with methoxy, etc.). n EXAMPLE: 4'-Chloromethyl-3,4,5-trimethoxybenzanilide. n USE: An antiulcer. n PREPARATION: An acid chloride shown by the formula R 2 COCl is reacted with an aminobenzoic ester in pyridine to give a compound shown by the formula II, which is reduced with aluminum lithium hydride in THF, and treated with thionyl chloride into a chlorine derivative and reacted with piperazine or N- methylpiperazine to give a compound shown by the formula I. n COPYRIGHT: (C)1986,JPO&Japio |