| abstract |
Disclosed is a compound having a good affinity for a trace amine-related receptor (TAAR), particularly TAAR1, which is effective in treating diseases related to the central nervous system. A substituted benzamide derivative represented by formula (I). [Effect] The benzamide derivative has selectivity for the TAAR1 receptor over the adrenergic receptor, and is depressed, anxiety disorder, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorder, mental disorder E.g. schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse, and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity It can be used for the treatment of dyslipidemia, disorders of energy expenditure and assimilation, disorders of body temperature homeostasis and dysfunction, disorders of sleep and circadian rhythms, and cardiovascular disorders. [Selection figure] None |