| abstract |
PURPOSE: To provide the titled emulsion having slow-releasing property, focal selectivity, and low side effect, applicable by intravenous injection, and useful as a drug such as vasodilator, hypotensor, etc., by using a fat emulsion containing prostaglandin E 1 alkyl ester. n CONSTITUTION: A fat emulsion containing the prostaglandin E 1 alkyl ester of e.g. formula (R is 1W30C alkyl) (abbreviated as PGE 1 E) is used as the titled agent. The fat emulsion is composed mainly of 5W50w/v% of soybean oil, 1W 50pts.wt., preferably 5W30pts.wt., based on 100pts.wt. of the soybean oil, of a phospholipid, and a proper amount of water. It may contain emulsification assistant, stabilizer, etc. The preparation is resistant to the inactivation of the drug component found frequently in the conventional PG preparation, and can be administered by intravenous injection. It has stable drug action, and is effective at a low dose. n COPYRIGHT: (C)1984,JPO&Japio |