| abstract |
NEW MATERIAL:A compound of formula I (R 1 is amino substituted heterocyclic group which may have a halogen; R 2 is carboxyl or protected carboxyl; A is lower alkylene which may be substituted by amino, protected amino, OH, oxo, etc.) or a salt thereof. n EXAMPLE: 7-[ 2-(2-Aminothiazol-4-yl)-2-carboxymethoxyiminoacetamido ]-3-vinyl- 3-cephem-4-carboxylic acid. n USE: An antimicrobial agent particularly a drug for oral administration having a high antimicrobial activity to prevent the growth of a wide range of pathogenic microorganisms including gram-positive and gram-negative bacteria. n PROCESS: A compound of formula II, a reactive derivative at the amino group or a salt thereof is reacted with a compound of formula III, a reactive derivative or a salt thereof to give the compound of formula I. n COPYRIGHT: (C)1981,JPO&Japio |