| abstract |
NEW MATERIAL:The titled compound of formula I (R is H, alkyl, alkoxy, or halogen; m is 1W3; n is 1W14). n EXAMPLE: 3-(2-Methylbenzoyl)-2'-deoxy-3',5'-di-O-propionyl-5-fluorouridine. n USE: Antitumor agent having high antitumor activity and low toxicity. n PROCESS: The compound of formula I is prepared by reacting 2'-deoxy-3',5'-di-O- alkylcarbonyl-5-fluorouridine with a benzoic acid halide of formula II (hal is halogen), e.g. benzoyl chloride, benzoyl bromide, etc., in a solvent such as ether, dioxane, etc., in the presence of a base such as trialkylamine, pyridine, etc. n COPYRIGHT: (C)1981,JPO&Japio |