| abstract |
PROBLEM TO BE SOLVED: To clarify a novel substituted imidazoline derivative, a method for producing the same and its use as a medicament. The present compound has the following formula I: Wherein B, E, W, Y, R, R 2 , R 3 , R 30 , e and h have the meanings indicated in claim 1. The compounds are suitable for treating and preventing inflammatory diseases such as rheumatoid arthritis or allergic diseases. The compounds are also inhibitors of leukocyte adhesion and migration and / or adhesion receptors V belonging to the integrin group. An antagonist of LA-4, which is generally a cell-cell or cell-matrix based on an undesired degree of leukocyte adhesion and / or disease caused by or associated with leukocyte migration or interaction of the VLA-4 receptor with its ligand. It is useful for treating or preventing a disease in which the interaction plays a role. Further, there is disclosed in the specification a process for preparing the compound of formula I. |