| abstract |
PROBLEM TO BE SOLVED: To provide a heterocyclic compound as a leukocyte adhesion inhibitor and a VLA-4 antagonist. (Where B, D, E, R, W, Y, Z, b, c, d, e, f, g and h have the definition defined in the claims), wherein the compounds are as inhibitors of leukocyte adhesion and migration and / or adhesion receptors VLA- belonging to the group of integrins. 4 antagonists. The compound is caused by or is associated with an undesirably wide range of leukocyte adhesion and / or leukocyte migration or VLA -4 for the treatment or prevention of diseases in which cell-cell or cell-matrix interactions play a role based on the interaction of receptors with their ligands, such as inflammatory progression, rheumatoid arthritis or allergic diseases Are provided. |