| abstract |
(57) [Summary] (Modified) [Problem] Anxiety and related diseases, central illness, exercise / feeding / Circulatory / lipid metabolism disorders, drug dependence, cancer, cerebral infarction, AID Provided is a drug having a high affinity for MDR, which has an effect of treating or preventing S, Alzheimer's disease, Huntington's disease and the like. SOLUTION: General formula 1 [Ar 1 and Ar 2 are the same or different and are substituted / unsubstituted phenyl or pyridyl group or naphthyl group, R 1 is hydrogen, substituted / unsubstituted C1-10 alkyl or alkoxy group, substituted / unsubstituted phenyl group or -NR 2 (R 3 ) (R 2 And R 3 is either represent the same or different hydrogen or an alkyl group of C1-10, shows a 4 to 10 membered cyclic amino group together with the adjacent nitrogen. ) X 1 is hydrogen, an alkyl or alkoxy group of C1-5, phenoxy, halogen, trifluoromethyl group, carbamoyl group or an aminosulfonyl group, Y 1 is an alkylene group of C1~6 without either having a branched chain or Indicates a single bond. ] The aryloxyaniline derivative of [1]. |