| abstract |
(57) [Summary] (With correction) [Solution] The following formula (I) Wherein X is an O atom or SO 2 ; R 1 is hydrogen, optionally substituted lower alkyl, optionally substituted aryl and the like; R 2 is hydrogen, lower alkoxy, lower alkylthio, or acylamino; 3 is hydrogen, lower alkyl, lower alkoxy, lower alkylthio, or acyloxy; R 4 is lower alkyl, lower alkoxy, lower alkylthio and the like; R 5 is optionally substituted carbamoyl, acyl and the like); A chymase inhibitor which is a pharmaceutically acceptable salt thereof or a hydrate thereof. [Effects] The above-mentioned oxacephem derivative or cephemsulfone derivative was found to have a chymase inhibitory action, and is useful for the prevention and treatment of various circulatory diseases and inflammation. |