| abstract |
(57) [Summary] (Modifications) [PROBLEMS] To provide a novel compound expected to have excellent pharmacokinetics as a therapeutic agent for Alzheimer's disease and an intermediate for producing the same. SOLUTION: (11E) represented by the following general formula [I] -5-amino-11-ethylidene-5,6,9,10- A tetrahydro-5,9-methanocycloocta [b] pyridin-2 (1H) -one derivative and a compound represented by the following general formulas [II] and [III], which are intermediates for producing the derivative. (Wherein, R 1 represents an alkyl group or a silyl group, and R 2 represents an alkyl group, an alkenyl group, or an aralkyl group. 1 to X 3 are -CH 2 OH, -CH 2 OCH 3 , -CHO,- COOH, -COOCH 3, represents a -CH 2 Cl and the like. Y represents -COOH, -COOCH 3, the -NHCOOCH 3 or the like. ) |