| abstract |
(57) [Summary] [Structure] General formula [I] (However, Ring A represents a substituted or unsubstituted monocyclic or bi- to tricyclic hydrocarbon group or a substituted or unsubstituted heterocyclic group, and Ring B is (1) Ring A is a substituted or unsubstituted monocyclic group. In the case of a cyclic hydrocarbon group, a substituted or unsubstituted di- to tricyclic hydrocarbon group or a substituted or unsubstituted heterocyclic group, (2) When ring A is a substituted or unsubstituted bi- to tricyclic hydrocarbon group or a substituted or unsubstituted heterocyclic group, a substituted or unsubstituted monocyclic or bi- to tricyclic hydrocarbon group or substituted or Represents an unsubstituted heterocyclic group, and Q is of the formula- O is a group represented by O-, Y is a group represented by the formula -O-, A lk is a lower alkylene group or the like, Z is a group represented by the formula —O—, R is a substituted or unsubstituted aromatic heterocyclic group, R 1 represents a hydrogen atom or the like. ) A sulfonamide derivative represented by or a pharmaceutically acceptable salt thereof. [Effect] This compound exhibits excellent endothelin antagonism. |