| abstract |
[Objective] The present invention relates to novel alkanesulfonamides and their use as active ingredients in the manufacture of pharmaceutical compositions. The present invention also provides methods for the preparation of these compounds, pharmaceutical compositions containing one or more of these compounds and their endothelin receptor antagonists, particularly in the treatment and prevention of diseases associated with the endothelin system. It is about use. The present invention also relates to the use of the above compounds for the treatment of diseases related to the role of endothelin, such as cardiovascular diseases, inflammatory diseases and proliferative diseases. |