| abstract |
(57) [Summary] [Structure] A biphenyl derivative represented by the formula (I) and a non-toxic salt thereof [wherein R 1 is alkyl, cycloalkyl; R 2 and R 4 are H, alkyl, alkoxy, halogen, CF 3 , cycloalkyl, trialkylsilyl; R 3 is H, acyl; R 5 is alkyl, cycloalkyl, p -Fluorophenyl; L is a group of formula (II) or formula (III)]. [Chemical 1] [Effects] HMG-CoA reductase inhibition and / or cholesterol biosynthesis inhibition and / or antioxidant effect, and hyperlipidemia, atherosclerosis, hypercholesterolemia, hyperlipoproteinemia, ischemic heart It is useful for prevention and / or treatment of diseases, coronary heart disease and the like. |