| abstract |
(57) [Summary] (Modified) [Structure] A compound represented by formula (I), a method for producing the same, and a pharmaceutical composition for inhibiting leukocyte elastase containing the compound. [In the formula, R is C 1-6 alkyl; R 1 is C 1-6 alkyl and the like; R 2 and R 3 are hydrogen, halogen, C 1-6 alkyl, C 1-6 alkoxy, di- (C 1- 6 alkyl) amino, phenyl and the like; or R 2 -R 3 is 3, Form a 4-methylenedioxy group or the like; M is hydrogen, C 1-6 alkyl and the like; R 4 is, for example, —C (CH 3) 2 -CO-N (C 2 H 5) - (CH 2) 2 -N (C H 3) - (CH 2) compounds rheumatoid arthritis of 2 -O-CH showing a 3, etc.] EFFECT formula (I), the chronic bronchitis, spondylitis, atherosclerosis, such as myocardial infarction connective tissue It can be expected to be a therapeutic drug for inflammatory diseases that cause destruction. |