| abstract |
(57) [Summary] (Corrected) [Configuration] The following formula Specifically, for example, N- [2- (phosphonomethylamino) -3- (4-biphenylyl) -propionyl]- The present invention relates to an N-phosphonomethyl-biaryl substituted dipeptide derivative represented by 3-aminopropionic acid, a pharmaceutically acceptable salt thereof, a pharmaceutical composition containing the same, and a method for preparing the same. EFFECTS These compounds are useful for treating conditions and disorders responsive to the inhibition of the native hendopeptidase EC 3.4.24.11, especially cardiovascular diseases such as hypertension, renal failure such as edema and salt retention, pulmonary edema and It is particularly useful for the treatment of congestive heart failure. |