| abstract |
(57) [Summary] (Modified) [Object] To provide peptides having inhibitory properties against human leukocyte elastase, methods for preparing them, and pharmaceutical compositions containing them. A peptide of formula (I) derived from trifluoromethyl ketone. Where R 1 and R 2 are (substituted) alkyl and A together with the nitrogen and carbon atoms to which it is attached, Represents a nitrogen-containing monocyclic or polycyclic structure, B is, for example, Base). [Effect] This compound is an emphysema, chronic bronchitis, acute respiratory distress syndrome in adults, cystic fibrosis, rheumatoid arthritis, glomerulonephritis, inflammation, ischemia-reperfusion syndrome, malignant cell invasion and diffusion phenomenon, It is useful for treating connective tissue degenerative diseases or skin aging. |