| abstract |
The object of the present invention is a benzothiazine derivative having the ability to inhibit 11β-HSD1 not only at the enzymatic level but also at the cellular level. The compound of the present invention is a compound represented by the general formula (I). In the context of the present invention, in particular R 1 represents hydrogen or OR 1 represents an ester or an ether. R 2 represents naphthyl, 1,2,3,4-tetrahydro-naphthalene, biphenyl, phenylpyridine, or substituted phenyl. R 3 represents methyl or ethyl, R 4 and R ′ 4 represent hydrogen. |