| abstract |
(57) [Summary] (Corrected) [Structure] Formula (I) (For example, in the case of n: 0, R 1 : , R 4 : H, R 5 : , R 6 : H, R 7 : -CH 3 , R 8 : H, R 9 : -OH, A cyclopropenone derivative represented by R 10 : H, R 11 : H) or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition containing the cyclopropenone derivative as an active ingredient. [Effect] This cyclopropenone derivative is It exhibits strong inhibitory activity against thiol proteases such as cathepsin B, cathepsin H, cathepsin L, and calpain, and is also excellent in oral absorbability, tissue translocation and cell membrane permeability, and is expected to have various uses as a drug. .. (For example, drugs for diseases such as muscular dystrophy, stroke, Alzheimer's disease, inflammation) |