http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0491089-A
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_14effe3850d2129f863b969dac4f1db8 |
| classificationCPCAdditional | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/Y10S435-842 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12N9-93 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P41-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12P17-182 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P17-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D475-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P41-00 |
| filingDate | 1990-12-10-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6fc6e69a192fa7abc70d345aa3f86b44 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b88b8d12c7b78948dbbb819fb31418d4 |
| publicationDate | 1992-03-24-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | JP-H0491089-A |
| titleOfInvention | Production of optically pure diastereoisomer of tetrahydrofolate compound |
| abstract | PURPOSE: To obtain an optically pure diastereoisomer, by enzymatic formylation of 6S-form in a 6R- and 6S-diasteroisomer mixture of tetrahydrofolic acid and separation of the product from the unreacted 6S-isomer, followed by cyclization and hydrolysis. n CONSTITUTION: Only the 6S-isomer in a racemic mixture of 5,6,7,8-tetrahydrofolic acid is converted into 10-formyl-5,6S,7,8-tetrahydrofolic acid with a formyl tetrahydrofolate synthetase derived from bacteria. The 10-formyl-6S-isomer is separated from the unreacted 6R-isomer, cyclized and hydrolysed to give a 5-formyl-6S-isomer. The separated 6R-isomer is chemically formylated, cyclized and hydrolysed to yield a 5-formyl-6R-isomer. When necessary, the 5-formyl product is converted into the corresponding acid to obtain a substantially pure (6R or 6S)-diasteroisomer. n COPYRIGHT: (C)1992,JPO |
| isCitedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-2009523740-A |
| priorityDate | 1989-12-11-04:00^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
Total number of triples: 24.