| abstract |
PURPOSE: To provide a skin-beautifying cosmetic containing a specific ascorbic acid derivative, having excellent skin-beautifying effect and storage stability and exhibiting improved vitamin C solubility. n CONSTITUTION: The objective cosmetic contains an ascorbic acid derivative of formula I [R 1 is group of formula II (R 3 and R 4 are H or CH 3 ; R 5 is 1-20C hydrocarbon group, etc.)] or formula III (R 2 is same as formula II). The compound of formula I can be produced e.g. by reacting a halocarboxylic acid with tocopherol in the presence of a base (e.g. K 2 CO 3 or NaOH) in a solvent (e.g. DMF or DMSO), reacting the resultant tocopherol carboxylic acid ether with 5,6-O-isopropylidene-L-ascorbic acid produced by the reaction of L-ascorbic acid and acetyl chloride and stirring the reaction product in THF, etc., in the presence of an acid to eliminate the protecting group. n COPYRIGHT: (C)1992,JPO&Japio |