| abstract |
NEW MATERIAL:A compound expressed by formula I (R 1 to R 3 and R 1 ' to R 5 ' are H, halogen, lower alkyl or lower alkoxy). n USE: Used as an aldose reductase inhibitor. Said compound is useful as remedy of diabetic complication having high safety. n PREPARATION: 7-hydroxy-3-phenylcoumarin derivative expressed by formula II is reacted with halogenoacetic acid ester (e.g. ethyl bromoacetate) and hydrolyzed to afford the aimed compound. n COPYRIGHT: (C)1991,JPO&Japio |