| abstract |
A novel form of CDDO methyl ester is provided. A triterpenoid compound, methyl 2-cyano-3,12-dioxoleana-1,9 (11) -diene-28-oate (CDDO methyl ester), can be prepared, for example, from a saturated methanol solution. It has a crystalline glassy solid form and a non-hydrated crystalline form. The glassy form exhibits a high bioavailability compared to the non-hydrated crystalline form. Each form of CDDO methyl ester is generally a solid dosage form and is a good candidate for use in the treatment of various disease states generally associated with inflammation. [Selection] Figure 1 |