| abstract |
NEW MATERIAL:A compound of formula I [R 1 is H, OH, nitro, amino, sulfo, lower alkenyloxy, (substituted) lower alkoxy, etc.; R 2 is OH, lower alkoxy, lower alkylsulfonyloxy, triazo, amino, etc.] or its salt. n EXAMPLE: 3-(2-Naphthyl)-5-methoxymethyl-2-oxazolidone. n USE: An antidepressant. Having reversible and selective inhibitory activity against monoamine oxidase-A, thus useful for the therapies and prevention of depression, senile depression, mood depression, volition depression, anxiety, insomnia, anorexia, etc. n PREPARATION: The objective compound of the formula I can be obtained by reaction between a naphthylcarbamic lower alkyl ester of formula II (R 3 is lower alkyl) and an oxirane of formula III in the presence of a base (e.g. triethylamine) at 50-150°C. n COPYRIGHT: (C)1991,JPO&Japio |