| abstract |
PURPOSE: To obtain a powdery or granular composition containing oil and fat, free from bleeding of oil and fat even at a high content of oil and fat and keeping sufficiently high strength in a drug-preparation process by using an oil and fat, a base for including oil and fat, a polyol, a base agent for absorbing oil and fat and a binder at specific ratios. n CONSTITUTION: The objective composition containing oil and fat is composed of (A) 1-70wt.% of oil and fat such as vegetable oil and pharmaceutical synthetic oil, (B) 30-90wt.% of a base for including oil and fat, e.g. partially hydrolyzed starch, hydrophilic protein or hydrophilic polysaccharide, (C) 1-20wt.% of a polyol, preferably a polyol which is liquid at ordinary temperature, especially glycerol, (D) 1-20wt.% of a base for absorbing oil and fat, preferably light silica and (E) 0.1-15wt.% of a binder, preferably polyvinyl pyrrolidone. Preferable amounts of the components are A≤60%, B=50-80%, C=2-5%, D=5-15% and E=1-5%. Four components other than the component B are uniformly mixed with each other, the component B is uniformly mixed into the mixture and the mixture is granulated and heated at about 60°C for 5min to afford the objective solid composition having high fluidity and containing oil and fat. n COPYRIGHT: (C)1991,JPO&Japio |