http://rdf.ncbi.nlm.nih.gov/pubchem/patent/JP-H0291088-A

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filingDate 1988-09-29-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a66f391877b97b7df3daee94334c1fc7
publicationDate 1990-03-30-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0291088-A
titleOfInvention Phosphite and nucleoside-3'-phosphite derivative and synthesis of oligonucleotide using the same
abstract NEW MATERIAL:A compound expressed by formula I [R is (CX 3 ) n CX m or formula II (X is H, F, Cl or Br; n is 1-3; m is 0-2, provided that m+n=3; R' is CN, NO 2 , halogen or halogenated alkyl; l is 0-6)]. n EXAMPLE: Tri(1,1,1,3,3,3-hexafluoro-2-propylyl)phosphite. n USE: A phosphite-forming agent useful in efficient synthesis of oligonucleotide. Nucleoside is subjected to phosphite formation to provide a novel phosphite unit which is an intermediate for synthesis of oligonucleotide. n PREPARATION: An alcohol expressed by the formula ROH is reacted with phosphorus trichloride at a ratio of alcohols of 3-4 equivalent based on phosphorus trichloride in the presence of tertiary salt such as pyridine of 3-4 equivalent in an inert solvent of THF, etc., at ambient temperature for 2-5hr. n COPYRIGHT: (C)1990,JPO&Japio
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