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filingDate 1988-08-11-04:00^^<http://www.w3.org/2001/XMLSchema#date>
inventor http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7b2f101756723925ed30f85fa6f7c056
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publicationDate 1990-02-19-04:00^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber JP-H0248525-A
titleOfInvention Remedy for peptic ulcer
abstract PURPOSE: To provide a remedy for peptic ulcer containing tocopheryl retinoate and high-viscosity hydroxypropyl cellulose, covering the digestive mucosa with the remedy by oral administration and capable of selectively keeping the active component to the ulcer site over a long period. n CONSTITUTION: The objective agent can be prepared by compounding (A) a drug preparation containing tocopheryl retinoate (an α-tocopherol vitamin A acid ester) as an active component with (B) 2-50wt.%, preferably 20-30wt.% (based on the whole agent) of a high-viscosity hydroxypropyl cellulose preferably having a viscosity of 1,000-10,000 cps, especially 4,000-6,500 cps as 2% aqueous solution at 25°C. The obtained drug exhibits the attaching and retaining effect on the gastric mucosa, keeps high concentration of the active component on the ulcer site and is expected to have improved utilization ratio based on the administered dose. The administration dose and period can be decreased compared with conventional remedy. n COPYRIGHT: (C)1990,JPO&Japio
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Total number of triples: 31.