| abstract |
NEW MATERIAL:A compound shown by formula I {R 1 is (halogeno) lower alkyl, lower alkenyl, (substituted) phenyl, etc.; R 2 is H, halogen, cyano or lower alkyloxy; R 3 is halogen or group shown by formula II to formula IV [R 5 and R 10 are H, lower alkyl, etc.; R 6 , R 7 and R 11 are H, (halogeno) lower alkyl, etc.; R 8 is H, halogen, lower alkyl, etc.; R 9 is H, halogen, lower alkyl, etc.; n is 3-5]; R 4 is halogen, -OR 12 , -SR 13 or -NR 14 R 15 (R 12 to R 15 are H, lower alkyl, etc..; R 15 is H or lower alkyl); X is S or O}. n EXAMPLE: 5-Amino-9-cyclopropyl-6,7-dirluoro-2,3,4,9-tetrahydroisothiazolo[5,4- b]quinoline-3,4-dione. n USE: An antimicrobial agent. n PREPARATION: A 2-mercaptoquinolone derivative shown by formula V (R is lower alkyl) is reacted with an electrophilic aminating agent in the presence of a base. n COPYRIGHT: (C)1990,JPO&Japio |